Zhi-pei Liang
Zhi-Pei Liang is co-chair of a Beckman Institute research theme, president of an IEEE society, and his name adorns numerous awards and patents. He is also considered one of the world’s premier researchers in the field of magnetic resonance imaging (MRI), an area where his group has made key advances, including for example, developing a technique that enables real-time imaging of a beating heart.
But when it comes to taking credit, Liang is quick to point to others, principally the students in his research group and the late Paul Lauterbur, his mentor and winner of the Nobel Prize for inventing MRI. Lauterbur and Liang co-authored a seminal engineering textbook on MRI titled Principles of Magnetic Resonance Imaging: A Signal Processing Perspective, that came out in 1999, four years before Lauterbur won the Nobel Prize in Physiology or Medicine for his work in the field.
Liang was lured to the University of Illinois in 1989 because of Lauterbur, who was his good friend for almost 20 years and a role model as a faculty member, researcher, and person.
“He was one of a kind,” Liang said. “But you had to be very close to him to truly appreciate what kind of person he was, and what kind of scientist he was. He was not only a genius but also a wonderful, caring person. He always had a unique way to look at a scientific problem, and came up with very creative solutions. He was no doubt the best scientist that I have ever met.”
The students in Liang’s research group and those he teaches as a Professor in the Department of Electrical and Computer Engineering also guide his efforts. His students have gone on to prominent positions in industry and academia while current and recent members of his group have won important paper awards and honors in the area of MR imaging research.
Our goal is to develop new generations of MRI technology to provide unprecedented capabilities for structural, physiological, and functional imaging. – Zhi-Pei Liang
“It is very satisfying to be able to impact the younger generation positively, be they your own children or students,” Liang said. “I feel just as happy as they do when they make good research progress and receive awards and recognitions for their hard work.
“Sometimes,” he added with a laugh, “I feel happier than they do.”
Liang is Co-chair of the Institute’s Integrative Imaging research theme, and leader of the MR Engineering Research group, which has a focus on developing methods for optimal acquisition, and reconstruction and processing of MR images, with applications toward functional neuroimaging, real-time cardiac imaging, and cancer imaging.
Liang describes his research this way: “Nuclear spins are one of the most interesting quantum-mechanical systems. Using the signals generated from these systems, MRI has revolutionized biology and medicine over the last three decades. However, current MRI technology has not yet fully exploited the potential of the nuclear magnetic resonance phenomenon to unravel the mysteries of biology and life. Our goal is to develop new generations of MRI technology to provide unprecedented capabilities for structural, physiological, and functional imaging.”
A key goal is developing MRI technology that can, for example, visualize disease for diagnosis at a stage when treatment can be most effective.
“Imaging technology has been traditionally focused on capturing biological anatomical information,” Liang said. “But if a disease is already to the level that you can see structural changes, that’s perhaps too late.